Virtual Student Mobility Programme with U of Edinburgh for Transdisciplinary Insights on R&D Topics

IIT Kharagpur and The University of Edinburgh, UK have launched a virtual student mobility programme to gain insights on water-energy-food-public health from diverse perspectives, and analysis of the same with a transdisciplinary approach. The programme would facilitate capacity building and gainful research toward inclusive and sustainable development.

The proposed virtual programme focuses on developing domain knowledge of the participants, particularly in the Indian context, integrating ideas and expertise through group activities on the thematic areas. Under this programme and identifying the issues, the participants will work under the mentorship of faculty members IIT Kharagpur and the University of Edinburgh, before opting for a possible physical mobility programme. 

“We expect this virtual mobility programme to be helpful to the students from both UK and India toward their fruitful participation in a possible physical mobility programme. Further, experiences and feedback from this virtual programme will also benefit the organizers to revise the structure of this proposed  physical mobility programme in the right direction and toward greater success,” said Prof. B C Meikap, organizing committee member at IIT Kharagpur.

Around 20 students from IIT Kharagpur and 20 students from The University of Edinburgh will participate in this programme over a period of five days during 24-28 May 2021. 

Talking about how the programme will help students at IIT Kharagpur, Prof. Pulak Mishra said, “It will provide understanding of the critical issues from diverse perspectives, and seeing the socio-economic and behavioural aspects through the lenses of the Edinburgh students as well. Such interactions, exchange of ideas, co-working and cross-learning will grow the critical and transdisciplinary understanding of the IIT Kharagpur students on this complex domain of water-energy-food-public health relationships.”

The issues and underlying dynamics of water-energy-food-public health relationships are quite complex in different socio-economic, policy and institutional setups. In addition to innovation and development of appropriate technologies in these areas, their acceptance, adaptation and outcomes depend on various social, economic, behavioural, cultural, policy related and institutional factors. Further, often these social, economic, policy and institutional aspects also set the directions for further research and development in the related areas. Such both way implications require sharing and convergence of knowledge, expertise and emerging issues in the related fields through rigorous brainstorming and exchange of ideas and collaboration in teaching and research. The virtual mobility programme is expected to create the right platform in this regards.

“The programme will offer our students, opportunities to enrich their knowledge and research aptitude under the mentorship of the renowned faculty members of the University of Edinburgh. Experiences from such a joint programme will also benefit the participating faculty members of IIT Kharagpur in strengthening their joint research proposals with Edinburgh counterparts,” added Prof. Bhagirath Behera.

Since 2010, the Mumbai office of the University of Edinburgh, led by Regional Director Amrita Sadarangani, has been instrumental in developing a network of impactful activities in India, ranging from research collaborations with leading universities through to student-centered activities such as the ‘Fashion Trek’. The Virtual Student Mobility programme will fit wonderfully within this ever-growing narrative. Further, it will take the academic collaboration between IIT Kharagpur and The University of Edinburgh forward. 

“The 20 participating Edinburgh students will become knowledgeable ambassadors for Indian people and culture, with expertise and insights they can bring to their further studies. In summer 2019, the University of Edinburgh’s Study and Work Away Service commissioned a study ‘Barriers to International Experience’. Students identified short-term opportunities such as this an important mobility option and this programme can become an exemplar for similar future initiatives.” said Prof. Neil Robertson from of The University of Edinburgh

IIT Kharagpur Study Predicts River Basin-wise Agricultural Droughts-North India Shows High Vulnerability

With inputs from Rituparna Chakraborty

Highlights:

  • The study predicts future status climate change-induced agricultural droughts across India.

  • More intense droughts in North, North-East and Central India are expected as compared to South India.

  • About 20 and 50% of the area in India is expected to face extreme and moderate agricultural droughts, respectively, by the end of the 21st century.

Farmers in India’s north, north-east and central regions may have to be more cautious of agricultural droughts in the future – reveals IIT Kharagpur study. The data shows a geographically contrasting change in future drought patterns that indicates more intense agricultural drought in north, north-east, and central India as compared to south India due to changing climate. 

The study conducted by research scholar Mayank Suman from the School of Water Resources and Dr. Rajib Maity, Associate Professor at the Department of Civil Engineering at IIT Kharagpur has been published in the Journal of Water and Climate Change. The researchers have identified vulnerable basins, out of a total of 226 sub-basins across India, considering the future agricultural drought. The area under drought is also expected to increase which might lead to about 20 to 50% of mainland India suffering from extreme to moderate agricultural drought conditions respectively, by the end of this century.

Trend of SSMI series for different future periods. The maps show the basin-wise trend of agricultural droughts in entire ‘future’ period upto 2100 and three epochs: E1 (2006-2035), E2 (2036-2070), and E3 (2071-2100) for the worst climate change scenario.

“Sub-basins in Northern India are expected to have a longer time under drought conditions followed by sub-basins in central India. Sub-basins in the Gangetic plain were also observed to exhibit high vulnerability to extreme drought conditions in future,” said Mayank Suman.

The recent studies on meteorological drought suggest more intense and frequent drought events due to changing climate.

“With climate change, air temperature is expected to increase, resulting in a drying tendency in soil moisture and streamflow along with higher and intense precipitation. The prediction of an increase in the area under drought has been made due to these probable changes. Many studies suggest that drought is expected to become more severe and frequent, and the areas under drought are expected to increase with local variation in the future,” remarked Prof. Rajib Maity.

With India’s steep dependence on agriculture and allied economies [18% of GDP, Source: Ministry of Statistics and Programme Implementation, Govt. of India, 2021], monitoring, assessment, and prediction of agricultural drought are of immense importance.

“With the extreme drought conditions having a possible adverse effect on food production in identified regions, policymakers would find our findings useful for future planning and preparedness in terms of agricultural productivity,” added Prof. Maity.

The researchers predicted the drought status using the wavelet-based drought temporal consequence modelling of meteorological drought with the best performing bias-corrected Coordinated Regional Downscaling Experiment (CORDEX) simulations, selected by Multi-Criteria Decision- Making frameworks. They used the Standardized Soil Moisture Index as the drought characterizing index alongwith most of the existing studies on meteorological droughts are analyzed using the indices, such as Standardized Precipitation Index, Standardized Precipitation Evapotranspiration Index, and the Palmer Drought Severity Index.  

About IIT Kharagpur: Indian Institute of Technology Kharagpur is a higher educational institute known globally for its graduate output and affordable technology innovations. Set up in 1951 in a detention camp as an Institute of National Importance, the Institute is ranked among the top five in India and has been awarded Institute of Eminence by the Govt. of India in 2019. The key areas of research of IIT Kharagpur are Affordable Healthcare Technologies, Advanced Manufacturing, Advanced Transportation, Precision Agriculture and Food Technology, Cyberphysical Systems, Ecology & Environment, Mining, Water Resources and Architecture. The Institute is engaged in several international and national mission projects and ranks significantly in research output including 50-100 IPR filed annually and about 2000 research publications in top journals and conferences. At present, the Institute has about 750 full-time equivalent faculty members, more than 14000 students and over 70000 Alumni. For more information visit: www.iitkgp.ac.in


Media Contact: Dr. Rajib Maity, Associate Professor, Email: rajib@civil.iitkgp.ac.in, Ph: +91-3222-283442

For more information write to media@iitkgp.ac.in

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Global Launch of COVIRAP – Nucleic acid-based Point-of-Care Diagnostic Device for COVID-19 and beyond

Highlights

  • A generic step-wise isothermal nucleic acid-based testing technology for the rapid diagnostics of pathogenic infections including but not limited to SARS-CoV-2 in individuals.

  • Nasal Swab/ Saliva to result from integration in about 45 minutes in a highly affordable pre-programmable portable device developed by the team, without requiring any separate facility for RNA extraction.

  • Kit supplemented with a free smartphone app to facilitate unambiguous results interpretation and automated dissemination to the patients. The test may be performed by unskilled personnel outside the controlled lab with no intermediate manual intervention between sample loading and result dissemination.

  • Patents filed in the India, USA, several other countries, and the foreign filing license has been granted recently.

  • The unique trade-off between the high scientific standards of advanced molecular diagnostics with the elegance of common rapid tests for underserved community care.

IIT Kharagpur has successfully commercialized its flagship healthcare product – COVIRAP – the novel diagnostic technology for infectious diseases including COVID-19 and beyond. The product developed by lead researchers Professor Suman Chakraborty, Dr. Arindam Mondal and their research group has been licensed for commercialization to the Rapid Diagnostic Group of Companies, India and Bramerton Holdings LLC, USA. 

Bramerton Holdings has signed a record deal for securing global rights for commercially disseminating the COVIRAP technology developed at IIT Kharagpur in various geographical locations outside the territory of the Indian subcontinent.  Rapid Diagnostic has also initiated adapting the COVIRAP technology platform for COVID-19 and tuberculosis, in collaboration with IIT Kharagpur.

The research team has now developed a more advanced version of COVIRAP using a step-wise isothermal nucleic acid testing technology for the rapid diagnostics of pathogenic infections including SARS-CoV-2 in individuals. The COVID-19 diagnostic test can be conducted directly from human swab samples in the portable device developed by the team, without requiring any separate facility for RNA extraction. The results can be made available within 45 minutes of obtaining the patient sample. The kit has also been also supplemented with a free smartphone app to facilitate unambiguous results interpretation and automated dissemination to the patients. 

Recognizing the impact of the COVIRAP technology in meeting the long-standing demands of high-quality community-level testing, IIT Kharagpur has further initiated the procedure of deploying this product for on-campus use to detect possible novel coronavirus infection.

“The above move has taken place at a critical juncture when the recent spurt in COVID-19 infection, commonly known as the second wave, has been threatening to spread more rapidly than ever before. Moreover, the commercialization of COVIRAP will initiate complete indigenization and availability of a large range of affordable healthcare products in the Indian market as well as deep trenches of a large global market that is literally starving for the need of such technology. COVIRAP promises its reach to the grass-root level in catering to the needs of the last person of the society,” opined Director Prof. V K Tewari.

For use of the test, the nasal, as well as oral swab samples, are diluted in a solution and tested in the portable device by mixing with reagents that are supplied in a pre-mixed form. The test runs automatically in the device without intermediate manual intervention.

“We have conducted field trials for running the tests with the help of unskilled personnel outside controlled laboratory ambiance, with no compromise in quality of the test outcome. The entire sample-to-result procedure may be conducted in the portable device, virtually anywhere and with minimal training thus making the process of testing more effective for community-level screening and early detection of any emerging infection outbreak. This may act as a key to arrest community level spreading of the infection,” remarked Prof. Suman Chakraborty.

Nucleic acid-based point-of-care tests such as COVIRAP usher great promises as viable alternatives for rapid testing of pathogenic infections at low cost in resource-limited settings.

“The COVIRAP test overcomes several potential bottlenecks faced by similar other tests in the past, for instance, poor performance outside highly controlled laboratory and lack of simple, affordable, yet generic and universal instrument that may be used for home-based testing and community healthcare for a wide variety of infectious and non-infectious diseases,” he explained.

Patents centered around this innovation have been filed in the India, USA, several other countries, in the name of IIT Kharagpur. The foreign filing license has been granted recently. Commercialization and use in the USA and Europe under the Emergency Use Authorization (EUA) process are currently underway. Both the Rapid Diagnostic Group in India and Bramerton Holdings in the USA, in association with IIT Kharagpur, have already identified the key resources towards establishing the reagent supply chain, kit and device manufacturing in entirety under a ‘Make in India’ initiative with complete import substitution. In addition to licensing COVIRAP to these companies, the inventors at IIT Kharagpur will receive further support via industrial consultancy project mode for further advancement of the product. 

The envisaged trade-off between the high scientific standards of advanced molecular diagnostics with the elegance of common rapid tests appears to be the future of infectious disease detection and management. A platform technology capable to be inclusive of all such disease detections where nucleic acid-based tests may be deployed, COVIRAP is not just a one-time solution targeted specifically to COVID-19 but will remain imperative in global disease management overall years to come.


For more information contact:

Research & Product: Prof. Suman Chakraborty, suman@mech.iitkgp.ac.in; Media: media@iitkgp.ac.in; VeenaNxt: info@VeenaNxt.com

Follow IIT Kharagpur on Facebook/Twitter: @IITKgp     Instagram: @iit.kgp


About IIT Kharagpur: Indian Institute of Technology Kharagpur is a higher educational institute known globally for its graduate output and affordable technology innovations. Set up in 1951 in a detention camp as an Institute of National Importance, the Institute is ranked among the top five in India and has been awarded Institute of Eminence by the Govt. of India in 2019. The key areas of research of IIT Kharagpur are Affordable Healthcare Technologies, Advanced Manufacturing, Advanced Transportation, Precision Agriculture and Food Technology, Cyberphysical Systems, Ecology & Environment, Mining, Water Resources and Architecture. The Institute is engaged in several international and national mission projects and ranks significantly in research output including 50-100 IPR filed annually and about 2000 research publications in top journals and conferences. At present, the Institute has about 750 full-time equivalent faculty members, more than 14000 students and over 70000 Alumni. For more information visit: www.iitkgp.ac.in

About COVIRAP Commercial Partners:

Rapid Diagnostic Group of Companies: Founded by Dr. Bharat Jindal, a medical doctor by profession, the companies were established in 1995 with the sole aim of providing quality and leading-edge products and services to the Indian Healthcare ecosystem. By now, they have established an extensive national network of 22 offices and 4,000 distributors, enabling outreach to customers at under-resourced locations where the infrastructure of high-end diagnostic tests remains non-existent. In response to the pandemic situation, they came into the production of COVID IgG ELISA kits with a joint venture of ICMR/NIV, Rapid tests, PPE kits, Masks and few more products which can help the Nation. Boosted by their own manufacturing facility of diagnostic tests based in Delhi, they envision bringing the COVIRAP technology to the Indian Market at the earliest. As a pioneer in the industry, their mission is to provide timely, high-quality diagnostic kits, diagnostic instruments, point of care and critical care instruments at an affordable price. They have also initiated adapting the COVIRAP technology platform for TB diagnostics, in collaboration with IIT Kharagpur.

Bramerton Holdings: Bramerton Holdings is a subsidiary of Riverfort Global Capital (ww.riverfort.com). The Riverfort Group comprises a London-based investment advisor regulated by the UK Financial Conduct Authority and a number of regulated investment funds and investment companies. In addition, the Riverfort group is an investor in the Sure Vally Ventures (SVV) venture capital fund which invests in early-stage technology companies and includes both private sector and governmental investors. The Riverfort Group and its founders have arranged and advised the funding of over 100 companies deploying over 500 million USD in capital. Bramerton Holdings is launching the special purpose vehicle for the global development and distribution of the COVIRAP technology via its subsidiary called VeenaNxt Limited. [Contact at info@VeenaNxt.com]

The  Bramerton Holdings leadership team includes Chairman Brian Kinane,  (MBA London & Columbia Business Schools) and BA (Computer Science, Trinity College Dublin) having more than 12 years investment fund management experience and 15 years entrepreneurial, corporate & operational experience across global technology giants; Gytis Martinkus, Managing Director & CFO, an experienced financial professional having qualified long-term association with the KPMG;  Subhendu K Misra, Managing Director US Markets, MBA (Columbia Business School, USA) and BS and MS (in Computer Science from Rensselaer Polytechnic Institute, USA), having over 20 years of experience at the intersection of life sciences, technology, and innovation, involving the top global pharmaceutical and medical devices companies across the US, Europe, and Japan; and  Mark Wheeler, Chief Legal Officer, a qualified practicing solicitor holding, by training LLB in law (University of Bristol) and LPC (University of Law, Guildford branch), having over 10 years of  experience as a qualified solicitor, and named as a key individual in small cap capital markets and up to £ 50m mergers and acquisitions transactions in the Legal 500, 2020 edition.The VeenaNxt Limited board of directors includes Richard Morgan and Peter Bains as a strategic advisor. Richard Morgan is on the VeenaNxt board of directors. Richard co-founded Celgene in 1987 and was on the board for 20 years, serving as Chairman and CEO before recruiting a new CEO.  He remained on the board for a further 10 years, serving on the Executive Committee and chairing the Compensation Committee until his retirement in 2008.  He was the Chairman of Quidel Corp, a NASDAQ listed company, and Polarean. Richard was also a Managing Partner at Wolfensohn Partners LP which followed 15 years at Schroders plc, then a leading British merchant bank. In 1982 he completed the Advanced Management Program at the Harvard Business School. Peter Bains is a strategic advisor to VeenaNxt. Peter is currently CBO and Executive Director of Mina Therapeutics, a privately held UK biotech company as well as Non Executive Director of Mereo BioPharma Group plc, a NASDAQ listed company and Indivior, a FTSE listed company. Peter was the Chief Executive Officer of Syngene International, which he successfully took public on the Mumbai Exchanges in 2015. Peter has over three decades of experience in the biotech and pharmaceutical industry, which included a 23-year career at GlaxoSmithKline, among other roles he was also a member of various GSK teams with strategic, operations, marketing, and business development responsibilities and a Member of the Board of Directors of GSK India.  He also served as the Representative Executive Officer and Chief Executive Officer of Sosei Group Corporation, a Tokyo listed biotech company. Their team profile for the exclusive launch of COVIRAP in the global market is boosted further by executive scientist Dr. Gopal Pattanayak, Staff Scientist at the University of Chicago in the life sciences space, as well as Dr. Ajaya K. Mohanty, an internationally recognized technology professional having played a leading role in developing private and public sector partnerships in scientific research, education and IT, and having advised and consulted on the National Supercomputing Mission and (Digital) Infrastructure in India and recipient of  an award bestowed by the President of India in 2017.

MoU with NCDC to Promote Developments in Cooperatives, Agriculture and Allied Sectors

Highlights:

  • This MoU will promote greater collaboration towards sustainable development in cooperatives, agriculture and allied sectors
  • It will involve advancement of training, action research, studies, policy analysis, policy advice, consultancy, monitoring, evaluation, system development and technology development.
  • It will provide support towards Formation and Promotion of Farmer Producer Organisation
  • It shall have opportunities for trainee/student exchange program including providing internships

IIT Kharagpur and the National Cooperative Development Corporation (NCDC) have signed an MoU towards greater collaboration in issues and areas related to the development of cooperatives, agriculture and allied sectors and to the holistic approach towards sustainable development.

The scope of the MoU will involve the advancement of training, action research, studies, policy analysis, policy advice, consultancy, monitoring, evaluation, system development and technology development. Both organizations will collaborate and supplement the utilization of resources and facilities on matters pertaining to ‘Formation and Promotion of Farmer Producer Organisation‘, with a focus on sustainable business, capacity building, training and skill development of stakeholders.

Furthermore, skilling of youth through trainee/student exchange program including providing internship opportunities to students or alumni will be pursued under the SAHAKAR MITRA -NCDC Scheme on Internship Program (SIP).

A Joint Working Group will also be set up to monitor various activities under the MoU and suggest necessary measures for its development.  

“IIT Kharagpur has been working in various skill development and sustainable development projects through various programs and outreach initiatives at the Dept. of Agricultural and Food Engineering and Center for Rural Development and Innovative Sustainable Technology. Strengthening the rural workforce and building sustainable solutions for them, would require more exposure of the students and researchers as well as the target groups and end-users. We believe this collaboration with NCDC will augment a holistic growth towards Atmanirbhar Bharat,” said Director Prof. V K Tewari.

Earlier in March this year, Mr. Sundeep Kumar Nayak, IAS – Managing Director of the NCDC, visited the Agricultural and Food Engineering (AgFE) Department and interacted with the faculty members. It was decided to take the discussion to next level of formal engagement between the Department and the NCDC. The Managing Director and Prof. R. Banerjee (Head of AgFE Department) agreed to join forces so that the relevant innovations could potentially be appropriated and eventually disseminated to empower rural India through cooperatives and FPOs.

Agricultural and Food Engineering Department of IIT Kharagpur, is the only department of its kind in the country’s IIT System. Since its inception in 1952, the AgFE Department has been serving the nation through high-standard research and development, teaching, and outreach. The Department is adequately experienced in the creation and dissemination of appropriate rural technologies through its recent flagship initiatives. Rural Technology Action Group, Design and Innovation Centre (DIC), NABARD-Agri Business Incubation Centre, and Rashtriya Krishi Vikas Yojana-Agri Business Incubator are such existing platforms at the AgFE that have successfully translated research ideas into meaningful prototypes that address agricultural and rural issues. For more information visit http://www.iitkgp.ac.in/department/AG.


Media Contact: Professor R. Banerjee, Head, Agricultural and Food Engineering Department, rb@agfe.iitkgp.ernet.in

For more queries write to media@iitkgp.ac.in

Follow us on social media Facebook – Twitter: @IITKgp; Instagram: @iit.kgp


About IIT Kharagpur: Indian Institute of Technology Kharagpur is a higher educational institute known globally for its graduate output and affordable technology innovations. Set up in 1951 in a detention camp as an Institute of National Importance, the Institute is ranked among the top five in India and has been awarded Institute of Eminence by the Govt. of India in 2019. The key areas of research of IIT Kharagpur are Affordable Healthcare Technologies, Advanced Manufacturing, Advanced Transportation, Precision Agriculture and Food Technology, Cyberphysical Systems, Ecology & Environment, Mining, Water Resources and Architecture. The Institute is engaged in several international and national mission projects and ranks significantly in research output including 50-100 IPR filed annually and about 2000 research publications in top journals and conferences. At present, the Institute has about 750 full-time equivalent faculty members, more than 14000 students and over 70000 Alumni. For more information visit: www.iitkgp.ac.in

Research scholar Jyotsana Priyadarshani talks about ‘organ-on-a-chip’ research

For over two decades, researchers at IIT Kharagpur have been working on the development of affordable, portable and remote technology in the healthcare domain. The School of Medical Science and Technology and the Microfluidics Lab at the Dept. of Mechanical Engineering have collaborated on several such projects.

In a similar work research scholar, Jyotsana Priyadarshani is pursuing her PhD in the area of “organ-on-a-chip” under the supervision of Prof. Soumen Das at the School of Medical Science & Technology and Prof. Suman Chakraborty at the Microfluidics Lab.

Her research focuses on utilizing the frugal fabrication technique and microfluidic applications to address the important features and geometrical complexities of microvasculature in vitro. Such bioengineered microfluidic platforms are potentially suitable for probing cellular dynamics as well as offering critical insights into cancer, cardiovascular diseases, offsetting the requirements of in vivo trials on animals and humans to a large extent.

Here is an interview on “Vigyan Patrika”, Jyotsana talks about her recently published paper titled “Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment” in Physics of Fluids journal.

Read Full interview: https://biopatrika.com/2021/04/16/interview-biomimetic-organ-chip-drug-screening/


Paper Abstract: 
On-chip investigations on tumor angiogenesis, hallmarked by the growth of new blood vessels from preexisting ones, have attracted significant interest in recent times, due to their exclusive capabilities of probing the detailed mechanisms of chemokine transport and visualization of cell-cell interactions that are otherwise challenging to capture and resolve under in vivo conditions. Here, we present a simulation study mimicking tumor angiogenesis microenvironment on-chip, with a vision of establishing the favorable conditions for stable and uniform gradients of vascular endothelial growth factor that plays a pivotal role in tumor progression. The model platform addresses different responses of endothelial cells such as chemotaxis, haptotaxis, and mitosis, under combined convection-diffusion transport in a micro-confined fluidic environment constituting collagen-based extracellular matrix. The model predictions emerge to be consistent with reported in vitro angiogenesis experiments and hold potential significance for the design of organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.

Citation: Jyotsana PriyadarshaniPrasoon AwasthiPratyaksh KaranSoumen Das, and Suman Chakraborty, “Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment” , Physics of Fluids 33,  031910 (2021)  https://doi.org/10.1063/5.0042487

SARS-CoV-2 Alters Lung Cell Metabolism – IIT Kharagpur Research Model Shows, Model Could Help Therapeutics

  • Model development by IIT Kharagpur researchers predicting alteration in metabolic reaction rates of lung cells post SARS-CoV-2 infection

  • The research would lead to a better understanding of metabolic reprogramming and aid the development of better therapeutics to deal with the viral pandemics

COVID-19 pandemic has been posing unprecedented threats to the whole world. Among its many perils is the cellular metabolic system of those who tested positive. Coronaviruses are known to hijack the metabolism of lung cells. This threat makes it absolutely imperative to understand the mechanism of metabolic reprogramming of host human cells by SARS-CoV-2.

Researchers at IIT Kharagpur have, for the first time, have reported a method to find an alteration in metabolic reaction rates inside lung cells when they are affected by virus/pathogens. As the method finds and reports critical aspects of physiology, which are affected by SARS-CoV-2 infection, it will enable the discovery of therapeutic targets.

“We have used the gene expression of normal human bronchial epithelial cells (NHBE) infected with SARS-CoV-2 along with the macromolecular make-up of the virus to create this integrated genome-scale metabolic model. The growth rate predicted by the model showed a very high agreement with experimentally and clinically reported effects of SARS-CoV-2,” said Dr. Amit Ghosh, Assistant Professor, School of Energy Science & Engineering, IIT Kharagpur.

Scientists have been trying to extract information from the human genome sequences for the past two decades to gather a better understanding of genetic disorders thus allowing us to penetrate deeper into the fabric of life and enable better therapeutics.

Talking about this new development researcher Piyush Nanda (B.Tech.-M.Tech Dual Degree, Biotechnology, 2020, currently a graduate student at Harvard University) explained, “In this model development, we have explored how metabolism works and how it is altered in diseases. Our work involved measuring how the tens of thousands or more complex chemical reactions change when biological cells are intruded on by an uninvited guest like SARS-CoV-2, which would help improve our understanding of diseases.” 

Using the power of genomics the researchers posed the operation of reactions as a set of mathematical equations and solved it to obtain which reactions are altered in the cells when SARS-CoV-2 infects a person.

“A better understanding of metabolic reprogramming would aid in the design of better therapeutics to deal with the COVID-19 pandemic,” remarked Piyush.

Further, the researchers have identified pathways like fatty acid synthesis and lipid metabolism that can be targeted by novel drugs. This model is based on genome-scale differential flux analysis (GS-DFA) in context-specific metabolic models.

“Analysis of the rates of all intercellular metabolic reactions in disease biology is opening up new avenues for therapeutic interventions. Numerous diseases lead to metabolic pathway alterations and it is becoming increasingly important to be able to quantify the difference under normal and diseased conditions. Using our method we have observed the alterations between diseased and normal metabolic states in the case of SARS-CoV-2 infection which have been proven using human patients data. The model will allow researchers to understand the wide spectrum of viruses that manipulate human metabolism and will help to design better therapeutics in COVID-19 treatment leveraging the power of systems biology,” added Dr. Ghosh.

In the case of SARS-CoV-2 infection, the researchers predict that lipid metabolism particularly fatty acid oxidation, cholesterol biosynthesis and beta-oxidation cycle along with arachidonic acid metabolism to be most affected which was confirmed with clinical metabolomics studies.

The research was published in the international journal PLOS Computational Biology 

Cite paper: Article Source: Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection Nanda P, Ghosh A (2021) Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection. PLOS Computational Biology 17(4): e1008860. https://doi.org/10.1371/journal.pcbi.1008860


For more information contact:

Dr. Amit Ghosh, Assistant Professor, School of Energy Science and Engineering, IIT Kharagpur,

E: amitghosh@iitkgp.ac.in; Mobile: +91-9635844538

Piyush Nanda, B.Tech.-M.Tech Dual Degree, 2020, Dept. of Biotechnology, IIT Kharagpur, Graduate Student, Harvard University,

E: piyush.wcame@gmail.com

Media Contact: media@iitkgp.ac.in

Follow us on social media: Facebook / Twitter: @IITKgp    Instagram: @iit.kgp


About IIT Kharagpur: Indian Institute of Technology Kharagpur is a higher educational institute known globally for its graduate output and affordable technology innovations. Set up in 1951 in a detention camp as an Institute of National Importance, the Institute is ranked among the top five in India and has been awarded Institute of Eminence by the Govt. of India in 2019. The key areas of research of IIT Kharagpur are Affordable Healthcare Technologies, Advanced Manufacturing, Advanced Transportation, Precision Agriculture and Food Technology, Cyberphysical Systems, Ecology & Environment, Mining, Water Resources and Architecture. The Institute is engaged in several international and national mission projects and ranks significantly in research output including 50-100 IPR filed annually and about 2000 research publications in top journals and conferences. At present, the Institute has about 750 full-time equivalent faculty members, more than 14000 students and over 70000 Alumni. For more information visit: www.iitkgp.ac.in


Media Coverage:

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IIT Kharagpur’s Essential Oil Extractor to Economize Betel Leaf Oil Production in India

  • Antimicrobial and antioxidant rich betel leaf essential oil finds wide use in industrial applications including medicines, cosmetics and chewable mouth fresher
  • The essential oil extractor reduces betel leaf wastage making essential oil production economically viable
  • The process increases yield by 16%, reduces process time by 44% and energy input by 30%

 

There have been many tales of Paan – in songs, history and literature, religion and culture for many millennia, across hierarchies of society, in South and South-East Asia. While the use of Paan as a mouth freshener is under the radar of health agencies for carcinogenic effects, however, the main component, i.e. Betel Leaf stays clear of health concerns. Rather it is considered beneficial in terms of digestion, stimulation of senses and fresh breath due to the presence of antimicrobial and antioxidant-rich essential oil.

Extraction of this essential oil from fresh and cured betel leaves is of high interest for industrial applications including medicines, cosmetics chewable mouth fresher which has a very large market in the world. However, the extraction processes suffer from low economic viability and wastage in the value chain of betel leaves.

Prof. Proshanta Guha and his research group from IIT Kharagpur’s Agricultural and Food Engineering Department have addressed this challenge by developing a novel betel leaf oil extraction technology that can improve the overall process efficiency. The extractor is capable of saving 44% of the time and 30% of the energy requirement while increasing the oil yield by more than 16%, as compared to the current process and apparatus popularly used.

Describing the equipment, Prof. Guha said, “It is a distillation unit with special modifications for recycling evaporated water which carries the vapors of essential oil from the distillation flask to the condensation unit. It has also a special device to minimize the formation of emulsion for increasing the recovery of essential oil.”

The extractor was envisaged to be affordable to the betel leaf growers since the cost of fabrication of the extractor was calculated to be ₹10,000 and ₹20,000 for 10L and 20L sizes, respectively.

“This could be easily maintained by the small farmers and would also be sufficient for the processing of surplus leaves in any average-sized Boroj (~0.02 ha) on a daily or weekly basis. About 10-20 ml of essential oil can be extracted by one person a day using an extractor in three shifts. The price of the oil varies from ₹30,000/- to about ₹1,00,000/- depending upon the quality of the oil, Mitha variety being costlier than the other varieties,” Prof. Guha remarked.

For large rural installations, the researchers have tried to improve the efficiency further by insulating the heat-radiating portions of the apparatus with cheap insulators. Use of fuel requirement can also be reduced substantially if the byproduct i.e. de-oiled exhausted leaves are used as fuel. They have further developed Microwave heating-based equipment to improve the efficiency of the extraction process and to increase the yield of essential oil. In this attempt, the extraction process was completed within about 50 minutes. Thus, there was a saving of time and energy by about 76% and 43% respectively.

India produces betel leaves worth ₹ 9 billion per year grossing as the largest producer of betel leaf in the world. However, achieving profitability remains a crucial challenge as a minimum of 10% of the produce is wasted every year and a large portion remains unsold or sold at throwaway prices during the glut season.

“This extractor equipment is expected to check such wastage and channel the surplus for various industrial products. Further the equipment can extract essential oil from other organic materials as well,” confirmed Prof. Guha.

It has been patented and transferred to more than 20 government and private bodies and more are underway.


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Faculty: pguha@agfe.iitkgp.ac.in

Media & Communications Cell: media@iitkgp.ac.in

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About IIT Kharagpur: Indian Institute of Technology Kharagpur is a higher educational institute known globally for its graduate output and affordable technology innovations. Set up in 1951 in a detention camp as an Institute of National Importance, the Institute is ranked among the top five in India and has been awarded Institute of Eminence by the Govt. of India in 2019. The key areas of research of IIT Kharagpur are Affordable Healthcare Technologies, Advanced Manufacturing, Advanced Transportation, Precision Agriculture and Food Technology, Cyberphysical Systems, Ecology & Environment, Mining, Water Resources and Architecture. The Institute is engaged in several international and national mission projects and ranks significantly in research output including 50-100 IPR filed annually and about 2000 research publications in top journals and conferences. At present, the Institute has about 750 full-time equivalent faculty members, more than 14000 students and over 70000 Alumni. For more information visit: www.iitkgp.ac.in


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IIT Kharagpur Law Students to Draft Real-time Patents for Institute’s Innovations

In 2006 IIT Kharagpur had introduced a new academic discipline in the IIT system – Intellectual Property Law, seed-funded by distinguished alumnus Dr. Vinod Gupta. Over the years, Rajiv Gandhi School of Intellectual Property Law, the law school at IIT Kharagpur has not only expanded its scope across all academic verticals of law education but has emerged as one of India’s top law schools. With  Intellectual Property Rights (IPR) still as the key domain, the school has been instrumental in promoting IPR workshops for young innovators. A few years back a drive was undertaken at the School to promote Geographical Indication tag for traditional crafts across the country. In the Spring semester, the School conducted project-based learning by enabling the law students to draft patent documents of actual innovations made by the researchers at IIT Kharagpur. 

“While we routinely conduct patent drafting exercises this is the first time we have adopted real-time patent applications prepared by the students. In its endeavour to enhance practical understanding for students, RGSOIPL has yet another time taken a unique approach not typically done in other law schools. Our law school students have the best benefit of being in an IIT system by meeting face to face the institute inventors who are working on high-end technologies and also understand the entire process of converting the invention disclosure to the patent application,” remarked Dean of the School Prof. Goutam Saha.

The process involved studying the invention disclosure and preparing the patent application with the claims in line with the statutory requirements under patent law and the examination practice. An innovator from IIT Kharagpur also participated in the session so that technical queries in relation to research works could be clarified. 

“Students of the law school have been involved in conducting patentability searches, participating in inventor interview meets to enhance practical knowledge. Further, as part of the Legal Aid and IP Facilitation Cell, they have been working along with the faculty of the School in conducting IP search and analytics,” said Prof. M Padmavati, Former Head of the School. She further opined on the background of the LL.B honours students who are from the engineering or science background and pursuing specialization in IP Law.

The exercise was facilitated by the IPR Cell of IIT Kharagpur. The drafted claims and patent specifications were evaluated by the patent attorney of the Institute. The patent attorney provided students important insights into the drafting of patent specifications and claims including the cross-jurisdiction practice.  The session was conducted with utmost regard to safeguarding IP and maintaining IP compliance.

To know more visit: http://www.iitkgp.ac.in/department/IP


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School: dean@rgsoipl.iitkgp.ac.in Media & Communications Cell: media@iitkgp.ac.in

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ERP Software Developed by IIT Kharagpur Adopted by other IITs

The Enterprise Resource Planning (ERP) software developed and extensively used by IIT Kharagpur is now to be adopted by IIT Ropar and IIT Jodhpur for institutional use. IIT Kharagpur has signed MoU with both the IITs for customization, installation and deployment of the ERP system.

“This indigenously developed software was deployed across all major functions of the Institute, to improve organizational administration and shifting operations to e-management, through both intranet and internet as well as desktops and mobiles. Close to 2000 of our teaching and non-teaching staff and more than 14000 students are using this software regularly; additionally, a large number of external people also access various modules for applications to our academic programs, guest house services, collaborators etc., achieving another milestone of Atmanirbharta,” remarked Prof. Virendra K Tewari, Director, IIT Kharagpur.

The modules covered in the commercial version of the software include Academics (including new Admissions), Career Development, Accounts, Human Resources, Purchase, Hall Management Centre, Continuing Education, Guest House and also Institute Works. The modules are menu-driven with role-based access and delegation facility, rule engine-based approval process and data-oriented based process definition.

The perpetual license cost of the software has been estimated at ₹ 2.5 crore including initial customization and installation support. That is followed by an annual consultancy cost of ₹ 50 – ₹ 75 lakh. The duration of the project is 18 months.

Prof. Chittaranjan Mandal, who is heading the ERP division at IIT Kharagpur said, “Our software is uniquely designed to provide circumspect support institutional function covering admissions, academics, placement, hostel management, recruitment for faculty and non-faculty positions, research and consultancy activities, accounts, institutional works, guest house management. Necessary end-user customization, training of staff to support operation and further customization and the user end is included within the scope of the MoU. We are enthused with the positive reception to our ERP by IIT Ropar and IIT Jodhpur.”

IIT Kharagpur has also been approached by other institutions for similar adoption of its indigenously ERP.

Contact:

Project Info: Prof. Chittaranjan Mandal, Email: chairman.erp@adm.iitkgp.ac.in; Media: media@iitkgp.ac.in

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Ozone and Ultra-filter based manufacturing tech to extend shelf life of packaged Sugarcane juice

Researchers at IIT Kharagpur have developed new process technology based on ozonization and ultra filtration for manufacturing shelf-stable sugarcane juice

Sugarcane juice is a refreshing drink with an enriched nutritional profile. The juice accommodates health components such as, phytonutrients, antioxidants, and vitamins (like Vitamins C&B) which offer quick relief from heatstroke, dehydration, constipation, jaundice, etc. by supplying instant energy. Owing to the absence of simple sugars and low glycemic index (30-40), its average intake by diabetic persons is also acceptable. However, the colour and flavour unique to the juice get deteriorated immediately after its extraction due to biological processes of browning and microbial fermentation. Its short shelf life limits its long term storage and marketing. Thermal treatments used to enhance the shelf life of sugarcane juice destroy its pleasant taste and aroma. Non-thermal methods hold promise in this regard.

Research scholar Chirasmita Panigrahi from the Dept. of Agricultural & Food Engineering, as part of her PhD research, has been pursuing a novel study on ozone assisted cold sterilization technology towards the shelf stabilization of sugarcane juice without heat or chemical. 

The process technology involves ultra-filtering and ozonization of the freshly extracted microfiltered juice followed by packaging under an aseptic environment. The combined membrane filtration and ozone treatment technology resulted in 7 log reduction in bacteria, 5 log reduction in yeasts & moulds and 85% inactivation of enzyme polyphenol oxidase. 

“This could minimize the juice fermentation and brown to a greater extent during storage. The combined technology treated juice could be successfully stored up to 12 weeks under refrigeration without any appreciable change in its bioactive and essential nutrients. The treated juice well retained its sensory characteristics especially the colour and flavour during storage,” confirmed Chirasmita.  

Her PhD work which is being supervised by Professor H N Mishra of the Agricultural & Food Engineering Department and co-supervised Professor Sirshendu De of the Chemical Engineering Department has been selected for the NRDC National Meritorious Invention Awards 2020 by the National Research Development Corporation, Government of India, New Delhi recently. 

For more information please contact Prof. H N Mishra at hnm@agfe.iitkgp.ac.in 

 

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