Digging Deep

Changes like that occurring at the Mining Engineering Department of IIT Kharagpur could lead to momentous changes for women in mining in India

Could the historically male-dominated mining industry be inching towards greater gender parity? The answer from IIT Kharagpur’s Department of Mining Engineering is yes. The department has seen a sharp rise in the number of female students in the undergraduate studies  – from a trickle of one or two in a year to 18 in the year 2019.

All the centrally funded technical institutes in India are mandated to increase the number of women graduating from these institutes. The number of female students admitted at IIT Kharagpur stood at 15% (with supernumerary seats created to make up the shortfall through JEE) in the year 2018, and 20% presently,  even including the Mining Engineering departments. In a matter of three years, these female students will be knocking on the doors of the mining companies for opportunities to work and to contribute to the safety, profitability and productivity of the industries.

In India, women were not permitted to work underground and even in surface mines, they were not allowed to work at night. Interestingly, coinciding with the change of decision in the female participation in undergraduate studies in mining engineering, the Ministry of Labour and Directorate General of Mines Safety which is a constituent body of the Ministry opened up through Gazette notification in 2019, hitherto unimaginable opportunities for underground employment for women. These opportunities cut across not only supervisory work but all types of activities of the mining profession.

According to the Directorate General of Mines Safety, the average daily employment of women in mines in 2011-12 accounted for 4.4% (24,294 females) of the total mining workforce which is considerably less compared to women labour force participation rate (22.5%) in India. The key occupations of engagement in the mining sector for women were reported as miners (mainly in the extraction of Iron, Gypsum, Magnesite and limestone), loaders and clerical and supervisory (Deloitte study on Human Resource & Skill Requirement Study for Indian Mining Sector, 2016).

Given that mining relies heavily on engineering talent, and women have proved that they can be capable engineers, the industry could gain a lot from greater diversity in its workforce and by having women in leadership roles. But the perception that mining is a ‘man’s job’, given the demanding nature of mining activity, has been a major contributing factor to the poor gender ratio. 

In modern day mining, where automation is the key, physical capabilities should not be a determining factor. Besides, there can be little doubts about the correlation between business growth and diversity. Companies with more women, specifically with women on their boards, have shown overall better performance: more efficiency, greater sustainability and higher profit margins.

Quite obviously, perceptions need to change, and at every level. At IIT Kharagpur, things changed in 2002-03, when the Department of Mining Engineering opened its doors to women at the undergraduate level.

Prof. Ashis Bhattacharjee, Professor at the Department of Mining Engineering, who was then Vice-Chairman of JEE, recalls the move. “We convinced the Joint Implementation Committee, the Senate approved the move and IIT Kharagpur, together with IIT BHU, began to offer Mining Engineering program to women.”

Things did not change overnight. The inflow of students at the undergraduate level remained a trickle.

“There were some exceptionally committed students though. One, B. Niharika of the 2012 batch worked in a top Australian mining company, before relocating to Hyderabad,” says Prof. Bhattacharjee. 

Perceptions also needed to change at a more fundamental level. And that seems to be happening now with more girls taking up mining.

“Before taking up Mining Engineering, I hardly knew what it was. But now I feel quite interested. There are so many facets to it,” says Samiksha Sharma, a 2nd year BTech Mining Engineering student, who has taken up Oil and Gas belt Testing and Enhanced Oil Recovery as her additional subjects. “Dual degree students can also specialize in Petroleum Engineering,” she reminds.

Like Samiksha, Niveditha Adari, a fourth year student, is also interested in the many opportunities that the Mining Engineering course at IIT Kharagpur leads to. She is interested in finance and management and as a Dual Degree student, she has ‘Financial Engineering’ as her specialization.

“I could go into operations research, which is an important part of mine planning. Or be part of finance planning for mining companies, where I could use my mining engineering knowledge.” 

Given the focus of the Mining Engineering Department of IIT Kharagpur, which is into interdisciplinary fields such as environment, health and safety, and so on, and the advantage of the varied specializations (Safety Engineering, Petroleum Engineering, Financial Engineering) women graduating from the Department will be open to varied roles both within the Mining sector and elsewhere. But what has also changed substantially for them is the government opening up to what is believed to be the “new realities” of society. Taking these realities into account, the Union government in 2019 lifted the restrictions of the Mines Act of 1952 and allowed women to work in underground mines and also in opencast or above ground workings of the mine during night hours.

“Somehow we need to prove ourselves,” says Samiksha, “About 20-30 years ago, when women were not common in Mechanical Engineering, if some of the women had not proved themselves, then others would not have followed in their path.”

Some, like Parama Mukhopadhyay, a PhD scholar at the Department of Mining Engineering, believe that the regulation is not enough and there are still enough restrictions in place to stall women’s full participation in hands-on mining (Read her story here).

“It is not about where women have greater scope. The idea should be that they can work everywhere,” says Prof. Sunita Mishra, who joined the Department in February 2020 and is the first lady to join the Mining Engineering faculty at IIT Kharagpur and probably in the country as well. A Mechanical Engineer, Prof. Mishra did her Masters in Tunnel Engineering from Mining Engineering from ISM Dhanbad and PhD in the area of Rock Dynamics from the Department of Civil Engineering at the IIT Delhi. Prof. Mishra, who is teaching Rock dynamics and mining machinery in the lab, is already a role model for students in the Department. 

As she exemplifies, and the girls of the Department are beginning to understand, proven skill and expertise will take them places. Samiksha’s worry is that if the industry will come around and change itself as fast as the changes are taking place with women and mining. “Rest assured,” say her professors, “This is just a transition, and things will fall in place.”

 

BES is the best

An Indo-Belgium SPARC workshop at IIT Kharagpur brought to the fore world-wide efforts to improve bioelectrochemical systems for wastewater treatment and bioenergy recovery

In a remote boarding school in Kisoro, Uganda – the Seseme Girls’ School – lighted toilets had changed the way the girls lived. Around 86% of the girls felt safer using the toilet at night, given that they now felt protected from male attackers and insects in the lighted enclosures. Many, in fact, were now more interested in science and enjoyed learning about technology.

Why? This is because their toilets were now powered by microbial fuel cells (MFCs) that ran on “Pee Power”, that is human urine, and they were much enthused by this fact, even to the extent of wanting the technology to be extended to their villages.

This boarding school is not the only one where such urinals are being used. In the Mathare Valley slums in Nairobi and in the Thandanani area of Durban, South Africa, where shipping containers had been modified to house settlers, these “pee-powered” urinals have become a part of life. Such urinals had also been used, and progressively improved upon, to handle the rush of the Glastonbury festival from 2015, said Prof. Ioannis A. Ieropoulos of the Bristol BioEnergy Centre of the University of the West England, who has patented the technology that was also being extended to some of the refugee settlements in parts of Europe.

Like several speakers at the recently-held (Feb 26-27, 2020) Indo-Belgium SPARC workshop organized by the School of Environmental Science and Engineering and the P.K. Sinha Centre for Bioenergy and Renewables at IIT Kharagpur, Prof. Ieropoulous argued the case for MFCs – which used waste as its feedstock to produce bioenergy and other valuable products –  as a platform technology for multiple uses, including sanitation, renewable energy generation, production of value-added products via elemental recycling and wastewater treatment.

Prof. Ludo Diels of the Antwerpen University, Belgium, IIT Kharagpur’s international partner for the workshop, in fact insisted that in order to meet the goals laid down by the Paris Agreement, bio-electrochemical systems (BES) for wastewater treatment and bioenergy recovery from waste were indispensable.

Prof. M.M. Ghangrekar

MFCs are one popularly adopted configuration of BES and perhaps the most promising. However, like other BES technologies that are electrode-based systems, there are problems to its upscaling. The workshop held at IIT Kharagpur titled “Upscaling and field scale application of bio-electrochemical systems for wastewater treatment and bioenergy recovery” focused particularly on these problems.

For BES to be relevant and sustainable, the scientific community had to work on several of its facets. As Prof. Makarand M. Ghangrekar, convenor of the workshop and Head of both the School of Environmental Science and Engineering and the P.K. Sinha Centre for Bioenergy and Renewables at IIT Kharagpur, pointed out, to make BES competitive with existing technologies, “the yield of electricity/valuables recovery need to be increased with emphasis on decreasing the fabrication cost of this device.” Dr. Deepak Pant from the Flemish Institute for Technological Research (VITO), Belgium, summed up the other challenges – the development of electrodes without precious metals, direct recovery systems of produced molecules, membrane systems for direct gas diffusion, catalyst development and upscaling of the electrochemical systems.

Dr. Deepak Pant

Research groups at IIT Kharagpur under Prof. Ghangrekar’s supervision are looking at several of these problems. And these were highlighted at the workshop. For example, the research efforts undertaken at IIT Kharagpur on the development of low-cost ceramic membrane separator and non-platinum based electrode catalysts for application in MFC.

Also, the efforts undertaken to develop efficient electrode material for further enhancing the power production of MFCs and to develop understanding on upscaling the device. Using the outcome, Prof. Ghangrekar’s group had installed a pilot-scale MFC based onsite sewage treatment system inside the IIT Kharagpur campus and at NTPC, Netra, New Delhi. Efforts were also being taken at IIT Kharagpur to develop microbial carbon-capture cell (MCC) for effective wastewater treatment in anodic chamber and further post-treatment in cathodic chamber for harvesting algae to be used as feed stock for bioenergy production.

Demonstration of Bioelectric toilet at IIT Kharagpur

In addition, research is being undertaken to develop microbial electro-synthesis (MES) cell for CO2 reduction and synthesis of various high value organic compounds. Microbial desalination cells (MDCs) are being developed for simultaneous organic matter removal from wastewater and desalination to produce reusable quality treated water. Prof. Amreesh Chandra, Department of Physics, IIT Kharagpur, also highlighted how his research team had created hollow nanoparticles as catalysts for the treatment of industrial waste water and the detection of volatile gases.

The Indo-Belgium workshop in fact brought to the fore new technologies and processes being developed by the scientific community throughout India and many parts of the world to improve the capabilities of BES. Like Prof. Ieropoulos, Dr Harold Leverenz of the University of California Davis, Ms Jeanne Sabin, also from the University of California Davis, and Dr S Gajalakshmi from the Centre for Pollution Control & Environmental Engineering, Pondicherry University, were working with human urine. Some of them were trying to see if pre-treatment of urine waste streams could optimize MFCs and maximize nutrient recovery from urine, which is high in nutrients. Others were looking to see if hybrid, self-powered super capacitive air cathode MFCs could be used for human urine treatment.

Gas diffusion electrodes (VITO), more efficient cathode catalysts, polyvinyl alcohol-based ion exchange membranes for microbial desalination cells, novel MFCs like sediment MFCs or auto-dripping MFCs or flat plate MFCs or clay-pot coupled MFCs, bamboo biochar as low-cost electrode material, forward osmosis technology, study of the bacterial isolates from MFCs or electrogenic bacteria growing in BES, the treatment of water from distilleries or dairy farm or secondary effluent water or pharmaceutical waste water, various reactor technologies, different kinds of catalysts, everything was considered at the workshop.

The most attractive feature of the workshop was the number of research scholars who talked about their ongoing work on different aspects of BES. As Prof. Ghangrekar pointed out, “more scientifically organized cross-discipline research efforts are required further to scale-up these [BES] systems to gain benefit of recovering useful energy/valuables from waste materials.” The Indo-Belgium workshop that showcased the ongoing work from different corners of the world, seemed to boost this effort.

IITKGP researcher wins DAAD PRIME fellowship

Congratulations to Sumana Ghosh, Postdoctoral Research Fellow at the Department of Electrical and Computer Engineering, Technical University Munich, for winning the DAAD PRIME fellowship! Sumana completed her PhD from IIT Kharagpur from the Department of Computer Science and Engineering in 2019 and is an experienced researcher with a demonstrated history of working in the field of embedded systems, real-time systems, and formal methods.

The DAAD PRIME (Postdoctoral Researchers International Mobility Experience) is an extremely coveted fellowship. Since its initiation in 2014 by the German Academic Exchange Service (DAAD), the fellowship is awarded to postdoctoral scholars for a period of 18 months to support their international mobility for collaborative research, including that in Germany. Only 2-3 candidates are usually awarded the fellowship in the ‘Engineering’ category, and this year, Sumana was among only 27 candidates out of 201 who were awarded PRIME, making her feat even more commendable.

Sharing the good news with her mentors – Prof. Soumyajit Dey and Prof. Pallab Dasgupta – Sumana wrote, “I really never thought of this outcome. It’s all about the courage, help, and support that I have got for the last 6 years.”

Sumana’s research interests are Design, Verification, and Analysis of Embedded Control Systems, Application of Formal Techniques in Real-Time Scheduling and Fault-tolerant Control Design Automotive Security, Cyber-Physical Systems Security and Formal Methods and Robotics. Her thesis topic was ‘Formal Approach towards Pattern Guided Scheduling in Embedded Control Systems’. She was part of the Formal Verification Research Group of the Computer Science and Engineering Department of IIT Kharagpur and has worked on FMSAFE (A Networked Centre for Formal Methods in Validation and Certification Procedures for Safety Critical ICT Systems) and AUTOSAFE (Architecture-aware Timing Analysis and Optimization of Safety-Critical Automotive Software) projects that are being conducted by the Institute.

She helped organize a two-day Indo-Israel joint research workshop between IIT Kharagpur and Ben-Gurion University, Israel, held at IIT Kharagpur in February 2016 and a one-day Indo-German technical workshop as part of the AUTOSAFE project in December 2015. Sumana received ‘Honorable Mention’ at the VLSID Conference in 2019. She was recipient of the Microsoft Research travel grant and ACM-India IARCS grant for attending ACM-SIGBED EMSOFT Conference 2017 in Seoul and was awarded scholarship for attending the international conference CAV 2016 and VMW workshop in 2016 in Toronto.

Bridging the divide

A novel Science Communication Conclave at IIT Kharagpur tries to bridge the gap between the scientific community and the media to pave the way for better news dissemination

Veteran science journalist Ms. T.V. Padma during her talk

February 28 was the day C.V. Raman went to the media to disclose to the world his discovery of the ‘Raman effect’. What better way to celebrate National Science Day, as this day is known, than re-energize the bond between the scientific community and its messengers and interlocutors – the media? That is precisely what IIT Kharagpur’s two-day Science Communication Conclave 2020 has done. This unique initiative of the Institute brought together top science journalists and communicators throughout India, researchers, faculty and students to deliberate on how best to disseminate news from the world of science and technology.

Prof. Sriman Bhattacharyya

In his address to the audience, Prof. Sriman Kumar Bhattacharyya, Deputy Director, IIT Kharagpur, pointed out, “National Science Day is a reminder of the importance of science dissemination and it should be done by any means possible.”

Was this task of dissemination of news related to science and technology anyway being jeopardized by scientists’ reservations about opening up to the media? Were journalists jeopardizing the intent and purpose of communication in their hurry to ‘break news’? Is scientific jargon serving as a barrier to the correct representation of scientific developments? Is science news becoming less popular? Could there be ways to spur its popularization?

Prof. Baidurya Bhattacharya, Dean, International Relations

The congregation of mediapersons, scientists, as well as students took a hard look at the issues at hand. Prof. Baidurya Bhattacharya, Dean, International Relations, convenor of the event, set the tone by opening the conclave with a presentation on the development of cloning technology that at once highlighted the follies and expected rigour of reportage on a scientific development. “There is an enormous need to disseminate factually correct information and at the same time to live up to the demands of the media industry,” said Prof. Bhattacharya.

Panel discussion on ‘Role of alternative media in science dissemination’

For some years now, science news have taken a backseat in traditional media. Supplements dedicated to science have been dropped and science news have shrunk often to half a page being devoted to it. Senior journalists, such as Ms. T.V. Padma and Mr. Dinesh Sharma, highlighted the problems facing science journalism today – organizationational constraints of the media houses who were dependent on advertisements, the preference for ‘breaking news’, low priority for science news vis a vis political news and news from the world of entertainment, the lack of mentoring of science journalists, the lack of infrastructural support or of networking bodies.

Dr. Meher Wan, , Editor of Indian Journal of Engineering and Materials Science

They also drew attention to what they called ‘communication bottlenecks’ with the scientific community that were adding to the troubles. Often, scientists’ unwillingness to publicly communicate on research and the lack of an institutional policy on communication complicated matters.

Despite the drawback, senior journalists such as Mr. Pathik Guha (Anandabazar), Mr. Amal Sarkar (Ei Samay), Ms. Padma, Mr. Sharma, Mr. B.R. Srikanth, and a younger crop, such as Mr. Mohamad Shafi Shamsi, Mr. Indrajit Kundu, Mr. Sujoy Dhar, or Mr. Shwetank Dubey, were making all out efforts to encourage public interest in science through innovative ways of story-telling or through the use of more visual elements such as infographics.

In fact, alternative media appear to be making a major advance in this respect by opening up ways for better and more impactful science communication. “We live in the times of ‘convergence media’,” remarked Mr Sujoy Dhar, correspondent for Reuters in Kolkata and a writer for Inter Press Service (IPS), pointing to the enormous advantages of online news dissemination.

Ms. Sahana Ghosh

Ms Satarupa Sen Bhattacharya, National Editor at Citizen Matters, an online civic media platform that researches and reports on critical urban issues, pointed out, “Online has a lot of space and can also experiment with different formats. It is a foregone conclusion that videos, podcasts and photoessays have a lasting impact and can catch a readers’ attention further.”

Ms Sahana Ghosh, staff writer with Mongabay, an international science news website, said, “With sound graphics, infographics, and other visuals, a story can be told in a wonderful manner. There is also scope for collaborations and cross-disciplinary work. The advantage for scientists lies in the fact that we can create high impact small packets of information and these are easy to digest.”

Ms. Ipsa Jain

The conclave also showcased the works of two science communicators with a difference – Ms Ipsa Jain, currently a Postdoctoral Fellow at the Institute of Stem Cell Biology and Regenerative Medicine, Bengaluru, who uses art and aesthetics as a vehicle for storytelling, and Lipsa Panda, currently working as a visual research communicator for the Lancet and FT commission, who also holds a PhD in Respiratory Immunology from CSIR- IGIB, Delhi. “Science cannot be breaking news but it has to be disseminated. A quick check and you will see that newspapers have 20 million readers, but Facebook has 2.9 billion, and YouTube 1.9 billion…. These are the platforms through which you can bring awareness about what kind of research you are trying to do, and this awareness can create interest so the audience will eventually demand to read science news,” argued Lipsa at a panel discussion on the ‘Role of alternative media in taking science to a wider audience’.

The poster exhibitions of the work of Ms. Jain and Ms. Panda at the conclave, which drew a lot of attention, clarified their point even better.

How could the scientific community help the media in its efforts for wider news dissemination? The discussions at the conclave seemed to suggest a few ways.

For one, greater cooperation between scientifists and mediapersons. “Remember, we are not adversaries. We need each other to take the news of science to the people,” said Prof. Pallab Dasgupta, Professor at the Department of Computer Science and Engineering, who was also panellist at the discussion titlted “Lab to media – bridging the language gap”.

A greater interaction with mediapersons, in fact, had helped both Prof. Abhijit Mukherjee, renowned hydro-geologist and Associate Professor, Geology and Geophysics, and Prof. Bhargab Maitra, a noted expert in urban planning and development, and transportation and Head of the Ranbir Chitra Gupta School of Infrastructure Design and Management and Professor at the Department of Civil Engineering at IIT Kharagpur, to make an impact at the level of policy-making. Both of them pointed this out during their talk at the conclave.

Another way that emerged from the discussions was training scientists and researchers on public communication. Several among IIT Kharagpur’s faculty acknowledged the need for it to ensure correct reportage of scientific developments. Some like Prof. Suman Chakraborty, Professor at the Department of Mechanical Engineering and Dean of the Office of Sponsored and Industrial Research Consultancy at IIT Kharagpur, had already started the initiative by asking his students to put down their research work in the simplest possible language. “The more effective the communication, the more effective the way the journalist can disseminate the news. In fact, this kind of training is part and parcel of advanced research for students around the world,” said Prof. Chakraborty.

Prof. Swagata Dasgupta

A host of IIT faculty talked about new and emerging areas of research. Prof. Swagata Dasgupta on protein chemistry, Prof. Sudeshna Sarkar on Artifical Intelligence, Prof. Saibal Gupta on ‘analogous studies’ of planetary topography, Prof. Chacko Jacob on nanomaterials and new materials, Prof. Brajesh Dubey on waste management, Prof. Sangeeta Bhattacharya on public health matters and Prof. Dilip Swain on food security. Many of them cautioned the media against hype.

Prof. Partha Pratim Chakrabarti

As Prof. Sunando Dasgupta, Professor at the Department of Chemical Engineering and Head of the Advanced Technology Development Centre, IIT Kharagpur, pointed out, “Science is a process of inquiry. You cannot expect breaking news to happen on a daily basis… For example, there can be no breaking news in cancer cure. It is an ongoing work and the steps that we take are at best incremental. But yes, scientists need to explain what they are doing. However, they are not trained to communicate what they are doing.”

Prof. Partha Pratim Chakrabarti, former Director of IIT Kharagpur, left a lasting impression with his concluding talk on Vigyan Katha Sagar, his proposed mission to take science to school children through Next-gen stories that embed principles of modern science and technology and enable critical thinking. Prof. Chakrabarti wrote, “The talk was inspired by the timeless masterpiece – Kathasaritsagar and its immense potential for a revisit. I illustrated the untapped power of simple age-old stories like Thirsty Crow in modern light and gave a sample of some of my own initial attempts at story-telling on problems solving and algorithm design meant for school students. Request others to share their ideas and possible stories.”

 

The evolving grammar of healthcare

The Clinical Biomarkers Discovery Laboratory at IIT Kharagpur is actively involved in using the newly emerged field of metabolomics, which is capable of providing biological end-point markers of the cellular processes that occur as a result of disease. The lab focuses on the use of metabolomics for comprehensive identification of disease biomarkers and understanding of the pathogenic mechanism underlying complex human diseases. Prof. Koel Chaudhury, who heads the lab, talks to the KGP Chronicle about how she has used the metabolomics approach to investigate women’s health, the progress her team has made and the future challenges.

Could you please give a brief summary of your research in the medical/life sciences domain?

The approach to illness and disease management has changed considerably with the evolution of medicine. In the past, medicine was strictly practiced according to the symptoms presented by the patient and was essentially based on the individual expertise of the physician, and thus was known as intuition medicine. Presently, medicine is based on the evidence produced by scientific research which also include the clinical trials, and is termed as evidence-based medicine. Most of the medical treatments today are designed for the average patient using the “one-size-fits-all” approach. Unfortunately, this type of treatment is seen to be very successful for some patients but not for others. In future, medicine is to be practiced according to algorithms that will take into consideration the patient’s characteristics, e.g. their genome, epigenetics, microbiomes, proteomes, metabolomes, environments and lifestyle to make diagnostic and therapeutic strategies precisely tailored to individual patients. It is envisioned that this will lead to the emergence of an effective P4 (predictive, preventive, personalized and participatory) healthcare system.

Our team uses the multi-omics approach including quantitative proteomics, NMR and mass spectrometry-based metabolomics to identify robust biomarkers in serum/urine/tissues/exhaled breath condensates/bronchoalveolar fluid which can assist in early disease prediction, identify disease sub-categories and predict individual disease risk. We also use ‘omics’-driven studies to enhance our understanding of the disease pathogenesis and monitor the therapeutic effect of drugs so that personalized therapeutic strategies targeting the underlying disease etiology can be developed.

What are the challenges that the research will help address?

Some of the clinical research questions our team is presently addressing using the ‘omics’ approach are listed below:

  1. What is the underlying cause of unexplained recurrent miscarriage?
  2. Can a set of biomarkers be developed for early prediction of spontaneous miscarriage (during first trimester of pregnancy, i.e. <12 weeks of gestation)?
  3. Can Stage I endometriosis (usually exists without signs and symptoms) be diagnosed early?
  4. What is the pharmacometabolomic effect of the drug dydrogesterone (a synthetic form of progesterone) in women with recurrent miscarriage?
  5. Is Asthma-COPD Overlap (ACO) a new disease entity?
  6. Can serum biomarkers replace the invasive right heart catheterization diagnostic procedure in patients with pulmonary hypertension?
  7. Is differential diagnosis of the two granulomatous restrictive lung diseases, chronic hypersensitivity pneumonitis (HP) and advanced-stage sarcoidosis possible?
  8. What is the effect of long-term doxycycline in improving COPD disease conditions?

In what stage of development is this research?

  • Potential markers have been identified in the exploratory patient cohort of various diseases; validation of these promising markers is ongoing in a fresh cohort of patients
  • Long term doxycycline as a possible therapeutic option for COPD is being explored
  • Robust serum biomarkers have been identified in early stage endometriosis; fabrication of a minimally invasive multiplexed point-of-care diagnostic device for detection of these markers is underway

 What is the future of this research?

Our research is translational and interdisciplinary in nature. We have active collaboration with clinicians and faculty members of various departments within the Institute. The aim of our team is to carry out ‘omics’-driven translational health research which will provide the ideal platform to diagnose diseases early in a non/minimally invasive and cost-effective manner.

How will the upcoming Dr B.C. Roy Institute of Medical Science and Research hospital help this work?

  • Large patient cohort is needed to generate error free data for biomarker discovery studies. The 400 bed hospital will provide the ideal set-up for such high-throughput data generation.
  • Integration of metabolomic data with metabolic imaging (PET-CT) and molecular imaging will be possible, which will provide a more holistic view to the perturbations caused by the disease
  • Discovering new drug targets, understanding drug mechanism of action at the proteome (pharmacoproteomics) and metabolome level (pharmacometabolomics), and the potential to investigate drug toxicity and resistance will become possible

Celebrating the ‘Macromolecule’

It was in 1920 that Hermann Staudinger, the legendary German organic chemist, proposed the concept of ‘macromolecules’. Since then macromolecules have revolutionized the materials sciences and biosciences and supported the rapid growth of the plastics industry. It is not without surprise that the Rubber Technology Centre of IIT Kharagpur, which has spearheaded research in rubber and polymers since its inception in the 1980s, should think it fit to celebrate the beginning of the second century of the macromolecule with the holding of the International Conference on ‘Green and Sustainability in Polymers and Functional Materials: Opportunity and Challenges’, particularly at a time when the environmental alarm bells have been ringing loud.

The conference, held under the aegis of MHRD’s SPARC scheme and in collaboration with the University of Melbourne, saw three plenary lectures and 14 invited lectures by distinguished scientists, faculty members and technologists from the academia and industry, who talked about the recent advances in green polymerization techniques, the development of new and sustainable functional materials and the use of these in diverse applications that ranged from the automobile industry to drug delivery.

Of particular interest was the plenary lecture of Dr Muthupandian Ashokkumar of the School of Chemistry, University of Melbourne, who talked about the use of ultrasound in polymerization. It is known that the interaction of sound waves and gas bubbles in liquids lead to acoustic cavitation, and that the force of this interaction has been used to prepare food emulsions and extraction of useful compounds from plants and other materials. Dr Ashokkumar’s team is using the technique to ultrasonically encapsulate, in the core of chitosan-shelled microspheres, a non-polar liquid nutrient. The method could not only be used to deliver nutrients, such as milk, fruit juice etc., but it could also be used for the encapsulation and targeted delivery of drugs.

Dr. Sivaram, IISER PuneIn his inspiring plenary lecture, Dr S. Sivaram from IISER, Pune took the audience through the fractious yet scintillating history of the discovery of the ‘Macromolecule’ and showed how polymer science is indebted not merely to Staudinger, but to a host of other scientists, starting from Michael Faraday in 1826 – who first noticed ethylene and butene differed in their gas density, but had the same elemental composition, and opened up immense possibilities – to Wallace Carothers – who gave polymers its most acceptable definition – to Herman Mark in the late 20th century, who led the way for the X-ray crystallography of Macromolecules to show that a molecule could be larger than its unit cell.

Dr Nikos Hadjichristidis from King Abdullah University of Science and Technology, Saudi ArabiaDr Sivaram also talked about the future possibilities of aliphatic polyesters such as polylactic acid (PLLA) and its competitive advantage over PET as a biodegradable, sustainable option. “There is still scope for new monomers and improved chemistry to tailor the structure and properties of aliphatic polyesters as a platform for sustainable materials.” Prof. Vimal Katiyar from IIT Guwahati too talked about PLLA and explained how bionanofillers could vastly improve the properties of PLLA.

If Dr Sivaram made a case to return to monomers from polymers, in other words, take a relook at monomers, Dr Nikos Hadjichristidis from King Abdullah University of Science and Technology, Saudi Arabia, strengthened the case by talking about developing new thermoplastic elastomers from old monomers.

Prof. Kinsuk Naskar of IIT KharagpurNew techniques for the development of new functional materials were elaborated severally by the speakers. Among them were Dr Sayam Sen Gupta from IISER Kolkata, who talked about fabricating porous materials through self-assembly of inorganic nanoparticles and silk proteins, Prof. Kinsuk Naskar of IIT Kharagpur, who gave an overview of the generation of thermoplastic elastomers and thermoplastic vulcanizates, and Dr Nabendu B. Pramanik from the Department of Chemistry, Lehigh University, USA, who talked about the development of hyperthin polymeric membranes for the separation of carbondioxide from flue gas as a way to fight global warming. Dr Hirendra N. Ghosh from the Institute of Nano Science and Technology, Mohali, elucidated on a new technique regarding metal-semiconductor interface that could majorly impact the production of solar cell and optoelectronic devices.

Dr Virendra Kumar Gupta from Reliance IndustriesBoth the industry representatives – Dr Virendra Kumar Gupta from Reliance Industries, and Dr Sujit S. Nair from Ceat talked about their initiatives in developing high performance elastomers with self-healing properties or functionalized polymers for new generation green tires that will make up 90% of the need of the automobile industry in the near future. Both of them talked about their company’s collaboration with IIT Kharagpur in the development of these polymers. “We have collaborative projects with different industries like major petrochemical industries in India and abroad, different tire industries, different rubber and polymer manufacturing industries in India and abroad, coating, paint industries etc.” reminded Prof Santanu Chattopadhyay, Head of the Rubber Technology Centre.

A major emphasis of the conference was on the use of various polymers for drug delivery. Dr Suhrit Ghosh from the Indian Association for the Cultivation of Science talked about the use of biodegradable polydisulfide in efficient drug delivery and drug release. Dr Braja Gopal Bag of Vidyasagar University, Midnapore, talked about the use of hybrid material –terpenoids – extracted from plants which showed great promise in drug delivery. Prof. Santanu Dhara of IIT Kharagpur talked about the various advances made by the Biomaterials and Tissue Engineering group of the Institute in the development of customized biodegradable implants and the use of biological wastes for development of biopolymers and materials for healthcare delivery.

Dr Nabanita Saha of the University Institute, Tomas Bata University, Czech Republic gave the audience an introduction to her work in the development of magnetic insoles to help blood circulation in diabetic patients and the future prospects of ‘magnetic hydrogel’, a biomaterial that involved a polymer matrix. Prof. Rajat Das of IIT Kharagpur also talked about the development of highly stretchable, strong dual cross-linked self-healing hydrogels.

The conference also included poster and oral presentations by research scholars and masters students. Prof. Nikhil Singha, one of the coordinators of the conference said, “I am extremely happy to note that masters students and participants from Kolkata, Contai, Midnapore as well as countries across the world are attending the conference.”

Outlining a heritagescape

 

A joint workshop at IIT Kharagpur tries to take heritage conservation from yearnings for the past to a vision for a resilient future

The Baluchari sari has long been accepted as a reflection of Bengal’s rich artistic heritage. Does this idea of heritage also stretch to lives of the people who make it? Would this heritage have been preserved without their role in the sustenance of this art through their generational participation in its making? Would Chhau dance, another unique heritage of Bengal, survive if the next generation of Chhau dancers do not learn the dance? When the Rajbanshis in Balagarh, a hamlet in Chinsurah along the Hooghly River that has produced boats for more than four centuries, give up their craft, will it not signify a fracture in Bengal’s centuries’-old riverine history that produced its cultural heritage?

Academics from IIT Kharagpur and beyond, activists, conservationist architects, and research scholars revisited these questions and raised new ones as they participated in a unique workshop titled “Urban Riverine Heritagescapes of Bengal: From Nostalgic Yearnings to Visions of a Resilient Future”, on January 28-29 organized by the Department of Humanities and Social Sciences in collaboration with the Rekhi Centre of Excellence for the Science of Happiness.

They not only agreed that cultural heritage is not confined to monuments and objects, but that it included traditions inherited from ancestors and passed down generations – such as the oral traditions, unique crafts produced by any particular community, performing arts, social practices, rituals, cuisine, festivals, knowledge and practices, and skills. In other words, that cultural heritage constituted both their tangible and “intangible” evidences. But they together emphasized that this heritage can only be sustained through intercultural dialogue, or “polylogue”, mutual respect, and the involvement of the community or common people. For unless it is recognized and valued as heritage by the communities, groups or individuals who create, maintain and transmit it, heritage cannot survive.

To facilitate this, the organizers of the workshop, Prof. Jenia Mukherjee and Prof. Anway Mukhopadhyay sought to promote the idea of ‘heritagescapes’, borrowing and furthering the concept of ‘scapes’ of noted anthropologist Arjun Appadurai, who showed how knowledge and culture flowed across different ‘scapes’ across the world instead of the binaries of North/South or East/West. “It is within such a framework of critical heritage studies which locates the heritagescapes within concrete (local as well as global) social and economic relations that one can situate the cultural heritage constellating around the urban riverine systems of Eastern India, especially Bengal,” explained Mukherjee and Mukhopadhyay, Assistant Professors, HSS Department.

The workshop, in fact, grew out of Prof. Jenia Mukherjee’s experiences with handling the ‘Hugli River of Cultures Pilot Project, from Bandel to Barrackpore’, a recently concluded project jointly funded by the by the Arts and Humanities Research Council, UK, and the Indian Council of Historical Research. Looking at the five former trading posts and garrison settlements along the Hugli River – Bandel, Chinsurah, Chandannagar, Serampore and Barrackpore – the project tried to evolve a sense of the ‘Hugli corridor’ by drawing on the collective history of the stretch and the role of the River in this geographical space.

That people are the ‘owner-custodians’ of Bengal’s heritage, and that even the quotidian heritage deserved to be preserved, was a key understanding that evolved from this work. It was this understanding that Prof. Mukherjee wanted to disseminate through the workshop.

The ‘river’ figured prominently in the workshop as it focussed on a cultural heritage that is largely a product of the historical experience, unique ecosystem and social, political and economic interactions fostered by the riverine system of Bengal. And not only because of that. The river, explained Prof. Partha Pratim Chakarabarti, who laid out the theoretical underpinnings of the conference, also encapsulated the true meaning of heritage. “River stands for the continuity, the flow of heritage. It gives the sense of timelessness and the idea of infinity… It is fluidic, continuous, in its upper motions, yet deep down it is still, unchangeable. Heritage is like that. It moves, changes with time, but it has stillness and steadiness, and yet it has that churning from which new things mingle the new with the old,” said Prof. Chakrabarti. Drawing from her empirical pool of project expertise, Prof. Sanghamitra Basu introduced the coupled nature-culture dimension to tap multiple meanings and interpretations making way to ‘heritagescapes’.

Within the spatial scale of Bengal and across pre-colonial, colonial and contemporary times, the workshop addressed vertical themes consisting of physical, cultural and ecological infrastructures and the complex intersections among these. Detailed empirical investigations and case studies within the ‘Bengal frontier’ involving marginalized social actors – such as that of the kumors of Krishnanagar and Nabadwip (Souvik Majumdar), the boat makers of Balagarh (Arpita C. Mukhopadhyay), waterscapes of Cooch Behar (Arjun Mukherji), conservation initiatives in Midnapore (Sanghamitra Basu), clay makers of Kumortuli (Amrita Sen), new fish epistemologies evolving in Sunderbans (Subodh Kumar Mandal), historical ethnography on ‘owner-custodians’ of Chandannagar (Lina Bose), protests by the Lepcha community against the Teesta Dam (Arpita C. Mukhopadhya), belief systems: River Damodar, Burdwan and Makar Sankranti (Anway Mukhopadhyay) and panel discussion involving IIT HSS and Rekhi Centre faculty members: Prof. Manas K. Mandal, Prof. Saamdu Chetri, Prof. Priyadarshi Patnaik and Prof. Anuradha Choudry, consultant architects such as Anindya Basu and activists like Yeasin Pathan from Pathra – facilitated a better understanding of the challenges and potentials of heritage conservation, management and governance. Prof. Anuradha Choudry elaborated the concept of HERITAGE as ‘Historically Enriched Right Interpretation using Technologically-aided Grassroots Engagements’ providing a comprehensive framework for designing next plans of actions by IIT Kharagpur.

To make the workshop lively and bring out the heritage-livelihoods connect, fishers from Sundarbans were invited to exhibit and narrate stories surrounding artefacts and ornaments designed by using marine fish scales.

The organizers plan to not only come up with a publication but design and develop feasible project proposals involving academia, policy circles, civil society and user groups in the future. “The Rekhi Centre of Excellence for the Science of Happiness will also come up with an exhibition to mobilize students and heritage experts and conservation agencies by April 2020 as an outcome or continuation of this workshop,” said Prof. Priyadarshi Patnaik, Head, Rekhi Centre, who was a key speaker and organizer of the workshop.

Marching Towards a Smart Campus

The Ranbir and Chitra Gupta School of Infrastructure Design and Management helps IIT Kharagpur develop a SMART campus

Indian Express,  Edexlive

Keeping up with the Government of India’s call to develop Smart cities, the Ranbir and Chitra Gupta School of Infrastructure Design and Management is not only developing the necessary expertise, knowhow and testing facilities, but new facilities set up in the School will help IIT Kharagpur itself develop a Smart campus.

Two new laboratories were recently inaugurated at the School – the Infrastructure Monitoring and Analytics Lab and the Infrastructure Evaluation Lab. Speaking on the occasion, the Director, Prof. Tewari, said, “The newly opened laboratories will help us monitor the health of buildings, bridges and other infrastructure. These laboratories will also help us to make better operational management of cities and infrastructure. There is an enormous potential for collaborative activities with public and private bodies for infrastructural projects and civic management.”

The Infrastructure Monitoring and Analytics lab, developed in association with Webel Technologies, will help in real-time monitoring of building, bridges, roads as well as air quality, temperature, humidity, and traffic. The lab is capable of collecting real-time data using various IoT devices such as video cameras, sensors and UAV. Some of these have already been set up at various points of the IIT Kharagpur campus. The data will be mapped and used for carrying out advanced analytics, modeling, simulation, etc. to formulate management policies. The effectiveness of various proposed solutions can also be evaluated based on the acquired data.

Prof. Bhargab Maitra, Head of the School, said, “Today, given governments’ emphasis on the concept of smart cities, all management and policy decisions are evidence-based. So getting real-time accurate data – both location and time-wise – is very important. The Infrastructure Monitoring and Analytics Lab includes a campus-wide IoT framework, where we will be able to collect data using heterogeneous data sources. With this data, we will be able to find out how energy is being consumed, how the movement of vehicles is happening, the emission level, water quality, the condition of infrastructure and so on. In other words, with this, the whole campus becomes an experimental lab and various disciplines and departments can access the data to develop meaningful solutions in different application domains such as traffic, water, solid waste, energy, building, road, etc. Once we are able to do this successfully in the IIT Kharagpur campus, we might be able to scale up and think of implementing it in a city level.”

The newly opened state-of-the-art Infrastructure Evaluation Lab has equipment that will be used to carry out non-destructive testing in order to evaluate the in-situ condition of any structure or its components. Sophisticated equipment such as Impact-echo set-up, Ultrasonic Pulse Velocity test instrument, Acoustic Emission Test Set-up, MIT-Dowel Scan, portable ground-penetrating radar and other such equipment will help assess the strength of existing buildings, bridges, roads, etc. The country is developing several concrete roads. The MIT-Dowel Scan, being set up for the first time by any lab in India, will be instrumental in evaluating these concrete roads including the dowel bars placed inside the pavement.

Mr. Ranbir (Ron) Gupta, who seed-funded the School in 2008, and was present during the inauguration of the new labs, expressed his happiness about the new developments in the School and the Department’s recent emphasis on industry experience through internships that has been made compulsory from last year for M.Tech students. He added, “We are thinking about bringing in the School’s alumni and have them talk about what they are doing now, how they have gained from their training here and what we can do to further improve the training and curriculum here.”

The School’s two-year multidisciplinary M.Tech program focuses on planning, management and effective delivery of large robust infrastructure projects in the areas of transportation, power, utility infrastructure and facilities.

Over the last seven years, RCGSIDM has produced four outstanding PhDs, over 150 M.Tech students and held several international symposiums, workshops and courses with renowned institutions like Columbia University, MIT, Georgia Tech, Lawrence Tech, University of Tokyo, Tokyo Metropolitan University, Curtin University and so on. The School is closely interlinked with two major ‘Mega Projects’ namely ‘Future of Cities’ and ‘SanDHI’ which are sponsored by the MHRD, Govt of India.

The School’s work on “Smart and Integrated Pedestrian Network Design” is funded by the MHRD under the UAY (Uchhatar Avishkar Yojana) and being executed in collaboration with Curtin University, Australia, IIT-BHU, Nikken Sekkei Research Institute, Japan and GMR Group.

An incredible moment

Times of India   India Education Diary

Close to 150 members of the Batch of 1970, together with their spouses celebrated their 50th graduation anniversary at IIT Kharagpur recently in a grand celebration titled the ‘Golden 2020 Reunion’ (from Jan 24-26). Batch members congregated from all over the world to commemorate the occasion with the twin inaugurals of ‘ADDA’ – their batch’s gift to the campus community,  along with the Alumni Clock Tower which now stands as a gift from the passionate Kgpians across the alumni batches.

The Clock Tower

The Alumni Clock Tower was inaugurated by Shri Amit Khare, IAS, Secretary, MHRD, Govt of India, who lauded the IIT Kharagpur alumni for their thoughtful gift to the campus community. “As the District Collector of Darbhanga, which had two clock towers, I often wondered the need for them when people had their wristwatches to look at the time. I soon realized that they were great socializing points. Both ADDA and the Alumni Clock Tower would be places of interaction and exchange of ideas, which is what great institutions facilitate,” said Mr. Khare during the inauguration.

The Clock Tower has been designed by renowned architect and alumnus of the Institute, the late I.M. Asthana, for whom this tower was the last project. Thanking the batch for their sustained support to the Institute, Director of IIT Kharagpur, Prof. V.K. Tewari, said, “The Clock Tower may be made to display more features in the future, such as digital display of the temperature, humidity or announcements of major events. IIT Kharagpur has the largest infrastructure, students, faculty as well as alumni of all the IITs. With this enormous resource, particularly the assistance and mentorship of the alumni, no dream is impossible to achieve.”

Mr Khare (third from right) with the other dignitaries at the Clock Tower inauguration

Mr. Arjun Malhotra, a pioneering figure in the Indian software industry, Co-Founder of HCL, and a top fundraiser among the Batch of 1970, suggested that a commemorative postage stamp could be released by the government  on the occasion of IIT Kharagpur’s 70th anniversary next year.

‘ADDA’, the batch’s gift to the campus on their golden anniversary, is an expansive area with a sculpted garden and varied seating arrangement. Renowned architect Abin Chaudhuri designed the gigantic red emblem that marks out the space. Speaking on behalf of the batch, Mr. Ranbir Gupta, President of the IITKGP Foundation USA and reputed US-based architect, said,”’ ADDA’ – which reads the same from left to right and right to left – means different things to different people, but it belongs to the IIT Kharagpur’s alumni, its students, its faculty, the staff and the entire community of IIT Kharagpur. This beautiful piece that sits at the crossroads on the campus is a small token of our appreciation for the Institute.”

The ADDA plaque

The Batch of 1970 was dubbed “The Incredibles” during the celebrations, and not without reason. Iconic Schools and Centres – G.S. Sanyal School of Telecommunications, Ranbir and Chitra Gupta School of Infrastructure and Design, PK Sinha Centre of Bioenergy, MN Faruqui Innovation Centre – have been founded by leading members of the batch. Batch leaders have also come forward to fund chair professorships, various flagship programs of the Institute, workshops, advanced tech labs, for yet to be instituted schools and academies and have also pitched in, together with other alumni, to reach internet connectivity to the hostels. Together they raised Rs 1.1 crore recently as a ‘Super Endowment Batch’, donating on behalf of even their departed classmates, to name a classroom in the Nalanda academic complex after their batch.

ADDA being inaugurated by Mr. Ron Gupta (second from right)

“The reason why the Batch of 1970 will remain a ‘Model Batch’ for all times to come is not because of a few of its active members. The synergy among the Batch is unique and incomparable,” said Prof. Subrata Chattopadhyay, Dean, Alumni Affairs. To enable batch members to relive their joyous student days, the Grand Reunion was held simultaneously with the Spring Fest. ‘The Incredibles’ were seen partaking Spring Fest’s unique fare of entertainment, that included top performers like Divine and Ritviz, from the front circles among the audience.

Together with alumni all over the world, members of the Batch of 1970 also contributed for the setting up of the Alumni Clock Tower. “This is going to serve as a beacon for the entire campus,” said Mr. Gupta, who, as President of the IITKGP Foundation USA, has led the fundraising efforts. On behalf of his batch, Mr. Gupta also promised to fund a ‘Center of Happiness’ and a ‘Hall of Fame’ in the premises of the Technology Students’ Gymkhana.

Batch of 1970 at the ADDA

“The Center of Happiness, to be established in association with the Rekhi Centre for the Science of Happiness, will be a huge space at the Gymkhana devoted to students’ wellbeing where they can pursue their individual interests, be it listening to music or practising yoga,” said Prof. William Mohanty, President of Technology Students Gymkhana. The Hall of Fame at the Gymkhana will record the major extracurricular achievements of the students.

Crafted from paper

Cell culture is integral to biological research. It provides a model to study the standard physiology and biochemistry of cells, the effect of drugs on cells, how cells behave under different culture environments. But the growing of cells on flat plastic surfaces does not accurately model their state inside the body. Hence scientists are increasingly using various three-dimensional (3D) cell culture strategies that allow cells to grow or interact with their surroundings in a way they actually do inside the body.

The prevalent 3D culture systems are mainly scaffolds, hydrogels and 3D printed models. Producing them is time consuming and requires a lot of technical skills. Often there are batch to batch variations. The base materials are also expensive. So, the development of cheap, portable and experimentally flexible 3D models has become necessary. A team of researchers at IIT Kharagpur has provided the answer by utilizing commercially filter paper for mammalian cell culture, which has been rarely reported.

Filter paper has often been used in making point-of-care devices (such as paper fluidics), but so far they have not been used this way. Composed of randomly arranged cellulose fibres, filter paper lacks cell adhesion motifs, making it amenable to being used as a paper substrate. However, for making it a suitable substrate, modification techniques had to be implemented. The main breakthrough achieved by this group is the use of a technique that makes it possible to fabricate cheap and affordable paper substrate for 3D mammalian cell culture.

The research group led by Prof. Tapas Kumar Maiti of the Department of Biotechnology, IIT Kharagpur has developed paper-based devices using LaserJet methodology (to defines cell culturable area) followed by (3-Aminopropyl)triethoxysilane (APTES) or glutaraldehyde/PAMAM treatment of the devices. This increases the interaction of the cell or other biological macromolecules (such as proteins/DNA) with the paper matrix. In order to further provide essential biochemical cues required to maintain physiological behavior of cells, they coated the amino-functionalized paper with natural extracellular matrix proteins.

Their results showed that the developed paper devices favoured the adhesion, proliferation, and 3D growth of multiple cell types including normal, transformed, cancerous, and stem cells as compared to the pristine paper matrix. These established 3D cultures on the paper matrixes (“in vitro paper-based tissue models”) could be extended for in vitro applications such as on-paper coculture models, on-paper gene expression analysis (immunocytochemistry/in-cell ELISA), drug screening and cell invasion assays. Further, such 3D culture could also be used to address relevant biological questions pertaining to cell-matrix interaction, cell-cell interaction, matrix confinement effects and so on.

It would be interesting to note that the cost incurred for procuring a conventional plate for coculture and transwell migration studies is Rs 7,000. The paper devices fabricated by the team of researchers at IIT Kharagpur cost Rs 100-200. Low media requirement and multiplexibility of the developed paper devices further cuts down the overall cost of biological assays.

The researchers also evaluated the systemic toxicity and antigenic response of the paper matrixes and found that the treated paper substrates significantly reduced the immunogenic response in the host, along with enhanced cellular infiltration and cell spreading of the infiltrated cells in the mouse model as compared to pristine paper substrates. This could provide the opportunity to use paper as a cheap and affordable substrate for the development of humanized animal models.

Prof. Maiti said, “Considering the simplicity, cost-effectiveness, and multiplexibility of the paper-based liver models, it is deemed to be ideal for developing cell-based bioassays especially in the resource-limited settings. Moreover, such technological advancement in the field of paper-based cell culture could open up new vistas in the field of biotechnology and engineering and could be used to disseminate the cell culture-related knowledge at the school/college levels.”

The team, consisting of Prof. Suman Chakraborty of the Department of Mechanical Engineering, Prof. Sudip Kumar Ghosh of the Department of Biotechnology and researchers Mr. Tarun Agarwal, Mr. Pratik Biswas, and Ms Aruja Rustagi from the Department of Biotechnology have applied for patent of their technology. The paper, ‘Biofunctionalized cellulose paper matrix for cell delivery applications’, was published in the International Journal of Biological Macromolecules ( Download paper https://www.sciencedirect.com/science/article/pii/S0141813019309109 and https://www.sciencedirect.com/science/article/pii/S0927776518305940)